2006
Jin, S. and White, E.
Role of autophagy in cancer: Management of metabolic stress
Autophagy.
2007 Jan 3;3(1).
PDF
White, E.
Mechanisms of apoptosis regulation by viral oncogenes in infection and tumorigenesis
Cell Death Diff.
13:1371-1377.
PDF
Mathew R, White E.
FLIPping the Balance between Apoptosis and Proliferation in Thyroid Cancer
Clin. Cancer Res.
12(12):3648-51.
PDF
Degenhardt, K., Mathew, R., Beaudoin, B., Bray, K., Anderson, D., Chen, G. Mukherjee, C., Shi, Y., Gelinas, C., Fan, Y., Nelson, D. A., Jin, S., and White E.
Autophagy promotes tumor cell survival and restricts necrosis, inflammation, and tumorigenesis
Cancer Cell.
2006 Jul;10(1):51-64.
PDF
Degenhardt, K. and White, E.
A mouse model system to genetically dissect the molecular mechanisms regulating tumorigenesis
Clin. Cancer Res.
2006 Sep 15;12(18):5296-304.
PDF
Tan, T.-T. and White, E.
Therapeutic targeting of death pathways in cancer
Programmed Cell Death in Cancer Progression and Therapy. Series Editors: Khosravi-Far, R. and White, E.; Springer, The Netherlands.
(in press).
2005
Marin, Y. E., Namkoong, J., Shin, S.-S., Raines, J., Degenhardt, K., White, E., and Chen, S.
Grm5 expression is not required for the oncogenic role of Grm1 in melanocytes
Neuropharmacology.
49 Suppl 1:70-9.
Gelinas C., White E.
BH3-only proteins in control: specificity regulates MCL-1 and BAK-mediated apoptosis
Genes Dev.
19(11):1263-8.
PDF
Lesne S, Gabriel C, Nelson DA, White E, Mackenzie ET, Vivien D, Buisson A.
Akt-dependent expression of NAIP-1 protects neurons against amyloid-beta toxicity
J Biol Chem.
280(26):24941-7.
Sundararajan R, Chen G, Mukherjee C, White E.
Caspase-dependent processing activates the proapoptotic activity of deleted in breast cancer-1 during tumor necrosis factor-alpha-mediated death signaling
Oncogene.
24(31):4908-20.
PDF
Tan T.T., Degenhardt K., Nelson D.A., Beaudoin B., Nieves-Neira W., Bouillet P., Villunger A., Adams J.M., White E.
Key roles of BIM-driven apoptosis in epithelial tumors and rational chemotherapy
Cancer Cell.
3:227-38.
PDF
For perspective see Bradbury, J.
Drug Discovery Today.
10: 9.
PDF
See also:
Cancer Biology & Therapy.
4:6, 631-634.
PDF
2004
Nelson, D. A., Tan, T.-T., Rabson, A. B., Degenhardt, K., and White, E.
Hypoxia and defective apoptosis drive genomic instability and tumorigenesis
Genes & Dev.
18:2095-2107.
PDF
For perspective see Flintoft, L.
Nature Reviews Cancer.
4, 754.
PDF
Nelson, D.A. and White, E.
Exploiting different ways to die
Genes & Dev.
18:1223-1226.
PDF
Ioffe, M.L., White, E., Nelson, D., Dvorzhinski, D., and DiPaola, R.S.
Epothilone induced cytotoxicity is dependent on p53 status in prostate cells
The Prostate.
9999: 1-5.
PDF
2003
Cuconati, A., Mukherjee, C., Perez, D., and White, E.
DNA damage response and MCL-1 destruction initiate apoptosis in adenovirus-infected cells
Genes & Dev.
17: 2922-2932.
PDF
White, E.
The pims and outs of survival signaling: Role for the Pim-2 protein kinase in the suppression of apoptosis by cytokines
Genes & Dev.
17(15): 1813-6.
PDF
Schwerk, C., Prasad, J., Degenhardt, K., Erdjument-Bromage, H., Tempst, P., Kidd, V. J., White, E., Manley, J. L., Lahti, J. M., and Reinberg, D.
ASAP, a novel protein complex involved in RNA processing and apoptosis
Mol. Cell. Biol.
23: 2981-2990.
PDF
Mikhailov, V., Mikhailova, M., Degenhardt, K., Venkatachalam, A., White, E., and Saikumar, P.
Association of Bax and Bak homo-oligomers in mitochondria. Bax requirement for Bak reorganization and cytochrome c release
J. Biol. Chem.
278: 5367-5376.
PDF
Perez, D. and White, E.
E1A sensitizes cells to tumor necrosis factor alpha by downregulating c-FLIP S
J. Virol.
77: 2651-2662.
PDF
2002
Cuconati, A. and White, E.
Viral homologues of Bcl-2: role of apoptosis in the regulation of virus infection
Genes & Dev.
16:2465-2478.
PDF
Degenhardt, K., Chen, G., Lindsten, T., and White, E.
Bax and Bak mediate p53-independent suppression of tumorigenesis
Cancer Cell.
2:193-203.
PDF
Sullivan, G., Garcia-Welch, A., White, E., Lutzker, S., and Hait, W.
Augmentation of apoptosis by the combination of bleomycin with trifluoperazine in the presence of mutant p53
J. Exp. Therap. & Oncol.
2:19-26.
Degenhardt, K., Sundararajan, R., Lindsten, T., Thompson, C., and White, E.
Bax and Bak independently promote cytochrome c release from mitochondria
J. Biol. Chem.
277: 14127-14134.
PDF
Cuconati, A., Degenhardt, K., Sundararajan, R., Anschel, A., and White, E.
Bak and Bax function to limit adenovirus replication through apoptosis induction
J. Virol.
76: 4547-4558.
PDF
Henry, H., Thomas, A., Shen, Y., and White, E.
Regulation of the mitochondrial checkpoint in p53-mediated apoptosis confers resistance to cell death
Oncogene.
21: 748-760.
PDF
2001
Sundararajan, R., Cuconati, A., Nelson, D., and White, E.
Tumor Necrosis Factor-alpha induces Bax-Bak interaction and apoptosis which is inhibited by adenovirus E1B 19K
J. Biol. Chem.
276: 45120-45127.
PDF
White, E.
Regulation of the cell cycle and apoptosis by the oncogenes of adenovirus
Oncogene.
20: 7836-46.
PDF
Sundararajan R., White, E.
E1B 19K blocks Bax oligomerization and Tumor Necrosis Factor Alpha-mediated apoptosis
J. Virol.
75: 7506-7516.
PDF
Shen Y., White E.
p53-dependent apoptosis pathways
Adv Cancer Res.
82:55-84.
2000
Thomas A., Giesler T., and White E.
p53 mediates bcl-2 phosphorylation and apoptosis via activation of the Cdc42/JNK1 pathway
Oncogene.
19: 5259-5269.
PDF
White, E., and Perez D.
TNF-alpha signals apoptosis through a bid-dependent conformational change in Bax that is inhibited by E1B 19K
Molecular Cell.
6: 53-63.
PDF
1999
White, E., and Prives, C.
DNA damage enables p73
Nature.
399: 734-737.
PDF
Medina, D.J., Sheay, W., Goodell, L., Kidd, P., White, E., Rabson, A., and Strair, R.K.
Adenovirus mediated cytotoxicity of chronic lymphocytic leukemia cells
Blood.
94(10): 3499-508.
Di Paola, R. S., Rafi, M. M., Vyas, V., Topmeyer, D., Rubin, E., Patel, G., Gooding, S., Medina, M., Medina, P., Zarnek, R., Zhang, C., White, E., Gupta, E., and Hait, W.N.
Phase I clinical and pharmacologic study of 13-cis retinoic acid, alpha interferon and paclitaxel in patients with prostate cancer and other advanced malignancies
J Clin Oncol.
7: 2213.
Zhang, C. C., Yang, J-M., White, E., Murphy, M., Levine, A., and Hait, W. N.
DNA damage increases sensitivity to Vinca alkaloids and decreases sensitivity to Taxanes through p53-dependent repression of microtubule associated protein-4
Oncogene.
16: 1617-1624.
Kasof, G. M., Goyal, L., and White, E.
Btf: A novel death-promoting transcriptional repressor that interacts with Bcl-2 related proteins
Mol Cell Biol.
19: 4390-4404.
PDF
1998
White, E.
Regulation of apoptosis by adenovirus E1A and E1B oncogenes in Seminars in Virology. Apoptosis in Virus Infection
eds. Academic Press.
8: 443-444, 505-513.
Han, J., Wallen, H. D., Nunez, G., and White, E.
E1B 19,000-Molecular-Weight interacts with and inhibits CED-4-dependent, FLICE-mediated apoptosis
Mol Cell Biol.
18: 6052-6062.
PDF
Han, J., Modha, D., and White, E.
Interaction of E1B 19K with Bax is required to block Bax-induced loss of mitochondrial membrane potential and apoptosis
Oncogene.
17: 2993-3005.
PDF
Perez, D., and White, E.
E1B 19K inhibits Fas-mediated apoptosis through FADD-dependent sequestration of FLICE
J Cell Biol.
141: 1255-1266.
PDF
Thomas, A., and White, E.
Suppression of the p300-dependent mdm2 negative-feedback loop induces the p53 apoptotic function
Genes Dev.
12: 1975-1985.
PDF
Zhang, C. C., Yang, Y.-M., White, E., Murphy, M., Levine, A. and Hait, W. N.
The role of MAP4 expression in the sensitivity to Paclitaxel and resistance to Vinca alkaloids in p53 mutant cells
Oncogene.
16: 1617-1624.
Chiou, S.-K., and White, E.
Inhibition of ICE-like proteases inhibits apoptosis and increases virus production during adenovirus infection
Virology.
244: 108-118.
PDF
1997
Kasof, G. M., Degenhardt, K., Perez, D., Thomas, A., and White, E.
A matter of life and death in Signaling pathways in apoptosis
Harwood, Levin & Watters.
pp. 1-28.
Sullivan, G. F., Garcia-Welch, A., White, E. Lutzker, S. and Hait, W. N
Augmentation of apoptosis by the combination of Bleomycin with Trifluoperazine in the presence of mutant p53
J Exp Therap & Oncol.
.
Chiou,S.-K., and White, E.
p300 binding by E1A cosegregates with p53 induction but is dispensable for apoptosis
J. Virol.
71: 3515-3525.
PDF
Rao, L., and White, E.
Bcl-2 and ICE family of apoptotic regulators: Making a connection
Curr. Opin. Genet. Dev.
7: 52-58.
Sakamuro, D., Sabbatini, P., White, E., and Prendergast, G.C.
The polyproline region of p53 is required to activate apoptosis but not growth arrest
Oncogene.
15: 887-898.
PDF
Sabbatini, P., Han, J., Chiou, S.-K., Nicholson, D.W., and White, E.
Interleukin 1 beta converting enzyme-like proteases are essential for p53-mediated transcriptionally dependent apoptosis
Cell Growth & Diff.
8: 643-653.
Rao, L., Modha, D., and White, E.
The E1B 19K protein associates with lamins in vivo and its proper localization is required for inhibition of apoptosis
Oncogene.
15: 1587-97.
PDF
1996
Han, J., Sabbatini, P., and White, E.
Induction of apoptosis by human Nbk/Bik, a BH3-containing protein that interacts with E1B 19K
Mol Cell Biol.
16: 5857-64.
PDF
Han, J., Sabbatini, P., Perez, D., Rao, L., Modha, D., and White, E.
The E1B 19K protein blocks apoptosis by interacting with and inhibiting the p53-inducible and death-promoting Bax protein
Genes Dev.
10: 461-77.
Rao, L., Perez, D., and White, E.
Lamin proteolysis facilitates nuclear events during apoptosis
J Cell Biol.
135: 1441-55.
PDF
White, E.
Life, death, and the pursuit of apoptosis
Genes Dev.
10: 1-15.
1995
Sakamuro, D., Eviner, V., Elliott, K.J., Showe, L., White, E., and Prendergast, G.C.
c-Myc induces apoptosis in epithelial cells by both p53-dependent and p53-independent mechanisms
Oncogene.
11: 2411-8.
Sabbatini, P., Lin, H.J., Levine, A.J., and White, E.
Essential role for p53-mediated transcription in E1A-induced apoptosis
Genes Dev.
9: 2184-92.
Lin, H.J., Eviner, V., Prendergast, G.C., and White, E.
Activated H-ras rescues E1A-induced apoptosis and cooperates with E1A to overcome p53-dependent growth arrest
Mol Cell Biol.
15: 4536-44.
PDF
Sabbatini, P., Chiou, S.-K., Rao, L., and White, E.
Modulation of p53-mediated transcriptional repression and apoptosis by the adenovirus E1B 19K protein
Mol Cell Biol.
15: 1060-70.
PDF
1994
White E., Chiou, S.-K., Rao, L., Sabbatini, P., and Lin, H.J.
Control of p53-dependent apoptosis by E1B, Bcl-2, and Ha-ras proteins
Cold Spring Harb Symp Quant Biol.
59: 395-402.
Chiou, S.-K., Rao, L., and White, E.
Bcl-2 blocks p53-dependent apoptosis
Mol Cell Biol.
14: 2556-63.
1993
White E.
Death-defying acts: a meeting review on apoptosis
Genes Dev.
7: 2277-84.
White E.
Regulation of apoptosis by the transforming genes of the DNA tumor virus adenovirus
Proc Soc Exp Biol Med.
204: 30-9.
Debbas, M., and White, E.
Wild-type p53 mediates apoptosis by E1A, which is inhibited by E1B
Genes Dev.
7: 546-54.
1992
Rao, L., Debbas, M., Sabbatini, P., Hockenbery, D., Korsmeyer, S., and White, E.
The adenovirus E1A proteins induce apoptosis, which is inhibited by the E1B 19-kDa and Bcl-2 proteins
Proc Natl Acad Sci U S A.
89: 7742-6.
PDF
White, E., Sabbatini, P., Debbas, M., Wold, W.S., Kusher, D.I., and Gooding, L.R.
The 19-kilodalton adenovirus E1B transforming protein inhibits programmed cell death and prevents cytolysis by tumor necrosis factor alpha
Mol Cell Biol.
12: 2570-80.
1991
White, E., Cipriani, R., Sabbatini, P., and Denton, A.
Adenovirus E1B 19-kilodalton protein overcomes the cytotoxicity of E1A proteins
J Virol.
65: 2968-78.
